Protein Sequencing market to Eyewitness Huge Marginal Growth by 2030

Posted by Mrudula Anil Karmarkar on January 16th, 2023

The global protein sequencing market size is expected to reach USD 1.77 billion by 2030, according to a new report by Grand View Research, Inc., expanding at a CAGR of 3.5% from 2022 to 2030. The increasing research in genomics and proteomics, coupled with the rising demand for protein-based therapeutics around the world, is contributing to the demand for protein sequencing. For instance, in May 2022, Amphista Therapeutics announced a collaboration with Bristol Myers Squibb for discovering and developing small-molecule protein degraders. Bristol Myers Squibb is expected to receive an exclusive license to manufacture and commercialize the product. Hence, the rising demand for protein degradation is anticipated to extend the application scope for protein sequencing.

Increasing funding and grants for biomedical R&D by governments and major companies are anticipated to have a significant impact on the usage of sequencing. As per a WHO report published in January 2022, in 2022, approximately 80,178 grants were awarded to biomedical research from 11 funders. Out of those, 69.4% of grants were assigned for research, while 19.5% were for training purposes. Moreover, approximately 75% of the overall grants were awarded to organizations in the U.S. Federal funding in the U.S. has created the demand for protein sequencing from end-users.

Similarly, the usage of recombinant antibodies is growing in the management of rheumatoid arthritis, cancer, and other pathological conditions, which is likely to increase the use of protein sequencing. According to research published in February 2022, the de novo antibody sequencing through mass spectrometry techniques is feasible for numerous complicated clinical samples via endogenous sources including serum. Hence, such research is likely to increase applications of the market in the area of therapeutics.

The COVID-19 pandemic resulted in increased usage of protein sequencing in assessing the components of the COVID-19 virus, along with assessing the changes in the genome post-COVID-19. A study published in September 2022 performed 97,437 COVID-19 protein sequencing to detect non-synonymous mutations in 26 various sequences. This had a positive impact on the global market.

The growing demand for personalized medicine and vaccination is likely to be an essential factor for the market growth since it is an emerging application of the market. For instance, in January 2022, Amgen collaborated with Generate Biomedicines in order to discover and advance protein-based therapeutics for multiple fields. The collaboration is estimated to be valued at around USD 1.9 billion.

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On the other hand, advancements in sampling technologies covering proteomes are expected to support the growth of the technique in the proteome market. However, the regulation on intellectual property such as patents on protein sequencing is not formally drafted. For instance, in Australia, a patent on sequencing highly depends on the jurisdiction. The lack of patenting regulations restrains academic institutions to conduct R&D on developing new technologies.

The market has witnessed a surge in revenue owing to the COVID-19 pandemic. The widespread nature of the virus compelled countries to perform protein sequencing on a large scale in order to gain insights for drug discovery. For instance, a research published in April 2021 employed protein sequencing for the comparative study between HIV-1 and COVID-19. The virus classification of HIV-1 and COVID-19 is crucial for COVID-19 drug discovery.

Protein Sequencing Market Report Highlights

  • By product and service, the service segment is projected to register the fastest growth rate during the forecast period. This can be credited to the increased funding and grants to academic institutions, such as the University of California and Yale University, to support their research in the biomedical application of the sequencing
  • By application, the bio-therapeutics segment held the largest share in 2021 and is anticipated to witness the fastest growth during the forecast period. This can be attributed to the increase in R&D investment for developing protein-based therapeutics and strategic initiatives such as fundraising
  • By end-user, the academic institutes and research centers segment held the largest share in 2021. This is owing to the presence of well-equipped facilities for research in developed countries
  • North America led the market in 2021 with a revenue share of over 35.0%. This is attributed to the increasing accessibility of funding opportunities for start-ups and academic institutions, along with the existence of key players in the region

The global market is surging owing to the outcome of advancing biomedical research and the rapidly growing R&D activities that support protein expression. Protein sequencing eases the detection of new biomarkers for the diagnosis of cancer and other diseases. Along with that, it improves the understanding of healthy cell functionality. However, the study of the diversity of proteins through the genome is still an untapped market.

Strategic initiatives by academic institutions in order to modify sequencing techniques for proteins are expected to support the rising market momentum. For instance, researchers from the University of Texas published developed technologies such as DNA sequencing for understanding protein. Fluorosequencing is a patented technology that offers comprehensive and rapid information regarding thousands of proteins. The inventors of the technology established a startup company, Erisyion Inc., to market the technology. The applications of the technology include Parkinson's disease detection and diagnosis, identification of antigen proteins for treating immune-oncology, detecting the camouflage system, drug development, and industrial biology.

List of Key Players in the Protein Sequencing Market

  • Thermo Fisher Scientific, Inc.
  • Shimadzu Corporation
  • Agilent Technologies, Inc.
  • Rapid Novor, Inc.
  • Charles River Laboratories
  • Proteome Factory AG
  • Selvita 
  • Bioinformatics Solutions Inc.
  • Creative Proteomics
  • Alphalyse 
  • Bruker

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Mrudula Anil Karmarkar

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Mrudula Anil Karmarkar
Joined: July 2nd, 2020
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