Ribosome and Cancer

Posted by Catalina Garcia on April 13th, 2024

The Role of Ribosome in Cancer

The ribosome consists of a variety of proteins and nucleic acids. It is responsible for translating mRNA information into functional proteins. Ribosome biogenesis involves several hundred accessory factors, and the ribosome function is coordinated by multiple cellular signals. The genesis and progression of spontaneous cancers are influenced by ribosome biogenesis dysregulation, which can be caused by the deletion of oncogenes or tumor suppressor genes, resulting in excessive ribosome activation. Mutations in genes encoding ribosomal proteins (RPs) or ribosome assembly components have been linked to the formation of sporadic human cancers. The molecular mechanism of ribosome biogenesis in cancer will provide opportunities to design new targeted therapeutics for cancer, such as drugs that inhibit ribosome biogenesis. Monitoring ribosome biogenesis, quality control mechanisms, and cellular checkpoints will establish the foundation for the development of novel targeted anti-cancer therapeutics.

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